Study M533
Study name | Cai L 2019 |
Title | Comorbidity of pain and depression in a lumbar disc herniation model: biochemical alterations and the effects of fluoxetine |
Overall design | The current study examined whether a lumbar disc herniation (LDH) model showed the behavioral and biochemical alterations that were in accordance with the characteristics of the comorbidity of pain and depression and tested the effect of fluoxetine on these measures. Wistar rats were divided into the following 4 groups: (1) control group (sham operation), (2) surgery group (lumbar disc herniation operation), (3) surgery + vehicle group (surgery plus vehicle treatment), and (4) surgery + fluoxetine group (operation plus fluoxetine treatment at the dose of 20 mg/kg, gavage twice daily). Hippocampal serotonin levels (n = 10) were measured by liquid chromatography-mass spectrometry. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Taste preference test, forced swimming test |
Sample size | 40 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: Prominence 20 A series UFLC System (Shimadzu, Kyoto, Japan) with an API 4,000 Qtrap MS System (ABSciex, Massachusetts, USA); |
PMID | |
DOI | |
Citation | Cai L, He Q, Lu Y, et al. Comorbidity of pain and depression in a lumbar disc herniation model: biochemical alterations and the effects of fluoxetine. Front Neurol. 2019;10:1022. |
Metabolite |
