Study M528
Study name | Emmerzaal TL 2020 |
Title | Chronic fluoxetine or ketamine treatment differentially affects brain energy homeostasis which is not exacerbated in mice with trait suboptimal mitochondrial function |
Overall design | The aim of this study was to test the hypothesis that chronic fluoxetine treatment in mice subjected to chronic stress would negatively impact brain bioenergetics. The FVB strain mice were subjected to a chronic unpredictable stress (CUS) paradigm for 21 consecutive days. Mice were divided into the following 3 groups (n = 13 in each group): (1) CUS group (stressor plus vehicle treatment), (2) CUS + ketamine group (stressor plus ketamine treatment), and (3) CUS + fluoxetine group (stressor plus fluoxetine treatment). Antidepressants were administered through daily intraperitoneal injection during the model building period. (15 mg/kg, in a volume of 1 ml/kg). Metabolic signatures of frontal cortex were measured using targeted metabolomics. |
Study Type | Type2; |
Data available | Unavailable |
Organism | Mouse; FVB mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Not reported |
Sample size | 39 |
Tissue | Central; Brain; Frontal cortex; |
Platform | MS-based; LC-MS: Waters Acquity UPLC system coupled with a Thermo Quantiva tandem mass spectrometer; |
PMID | |
DOI | |
Citation | Emmerzaal TL, Jacobs L, Geenen B, et al. Chronic fluoxetine or ketamine treatment differentially affects brain energy homeostasis which is not exacerbated in mice with trait suboptimal mitochondrial function. Eur J Neurosci. 2020. |
Metabolite |
