Study M521
Study name | Sekar S 2019 |
Title | Neuro-metabolite profiles of rodent models of psychiatric dysfunctions characterised by MR spectroscopy |
Overall design | To test metabolic alterations within the glutamate-cycle and in other major neurochemicals, single-voxel Magnetic Resonance Spectroscopy was recorded within the hippocampus in both rat models and control animals. Rats were divided into the following 2 groups (n = 12 in each group): (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 4 weeks. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 24 |
Tissue | Central; Brain; Hippocampus; |
Platform | MRS; MRS: 9.4T MRI (Bruker Biospin GmbH, Ettlingen, Germany); |
PMID | |
DOI | |
Citation | Sekar S, Grandjean J, Garnell JF, et al. Neuro-metabolite profiles of rodent models of psychiatric dysfunctions characterised by MR spectroscopy. Neuropharmacology. 2019 Mar 1;146:109-116. |
Metabolite | myo-Inositol/(Creatine and Phosphocreatine) ratio; GABA/(Creatine and Phosphocreatine) ratio; Glutamine/(Creatine and Phosphocreatine) ratio; Taurine/(Creatine and Phosphocreatine) ratio; (Phosphocholine and glycerophosphocholine)/(Creatine and Phosphocreatine) ratio; |
