Study M519
Study name | Prabhu VV 2019 |
Title | Metabolite signature associated with stress susceptibility in socially defeated mice |
Overall design | The present study aimed to identify the neurochemicals in select brain regions of mice exposed to social defeat stress. Adult C57BL/6N mice were subjected social defeat stress for 10 days. Using high-resolution magic angle spinning 1H nuclear magnetic resonance (HR-MAS 1H NMR), untargeted metabolomes were measured in the amygdala (AMG), dorsal hippocampus (dHIP), dorsal striatum (dST), and prefrontal cortex (PFC). Mice were divided into the following 2 groups: (1) control group, (2) SDS group. After stress, mice in the SDS group were divided into susceptible and unsusceptible groups based on a social avoidance test. Ten samples per group were used for metabonomic analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6N mouse; |
Categories of depression | Animal model; Social defeat model; Social defeat model; |
Criteria for depression | Social avoidance test |
Sample size | 20 |
Tissue | Central; Brain; Amygdala; Central; Brain; Dorsal hippocampus; Central; Brain; Dorsal striatum; Central; Brain; Prefrontal cortex; |
Platform | NMR; NMR: AVIII 700 spectrometer (Bruker Biospin, Rheinstetten, Germany); |
PMID | |
DOI | |
Citation | Prabhu VV, Thong NB, Cui Y, et al. Metabolite signature associated with stress susceptibility in socially defeated mice. Brain Res. 2019 Apr 1;1708:171-180. |
Metabolite |
