Study M507
Study name | Gulbins A 2018 |
Title | Antidepressants act by inducing autophagy controlled by sphingomyelin-ceramide |
Overall design | The aim of this study was to test whether antidepressants regulate autophagy by a modification of cellular sphingolipids. The concentration of ceramides and sphingomyelins in hippocampus of of wild-type mice were measured by HPLC-MS. The mice were (1) stressed with corticosterone, (2) treated with amitriptyline, (3) stressed with corticosterone and treated with amitriptyline for 5 or 12 days, or (4) left untreated. Amitriptyline (120 mg/L) was administered to mice for 5 or 12 days via their drinking water. |
Study Type | Type3; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Not reported |
Sample size | 10 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: 1200 series high-performance liquid chromatograph (HPLC) with quadrupole time-of-flight (QTOF) 6530 mass spectrometer (Agilent Technologies, Waldbronn, Germany); |
PMID | |
DOI | |
Citation | Gulbins A, Schumacher F, Becker KA, et al. Antidepressants act by inducing autophagy controlled by sphingomyelin-ceramide. Mol Psychiatry. 2018. |
Metabolite |
