Study M506
Study name | Fang GX 2018 |
Title | Effects of rTMS on hippocampal endocannabinoids and depressive like behaviors in adolescent rats |
Overall design | In this study, rats were divided into the following 4 groups (n = 10 in each group): (1) control group, (2) CMS group, (3) rTMS group, (4) CMS + rTMS group. The CMS stress procedure lasted for 3 weeks, then rTMS was performed for seven consecutive days, and the anti-depressive effects were evaluated by behavioral tests including the sucrose preference test, the forced swimming test, and the novelty suppressed feeding test. Expression of hippocampal cannabinoid type I receptor (CB1R), 2-arachidonoylglycerol (2-AG) and relative synthetase and degradative enzymes-diacylglycerol lipase (DAGL) and monoacylglycerol lipase (MAGL) were also investigated. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 40 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: 1100 LC system (binary pump and autosampler; Agilent) with API 4000 mass spectrometer (Applied Biosystems); |
PMID | |
DOI | |
Citation | Fang G, Wang Y. Effects of rTMS on hippocampal endocannabinoids and depressive like behaviors in adolescent rats. Neurochem Res. 2018;43(9):1756-65. |
Metabolite |
