Study M505
Study name | Vinod KY 2012 |
Title | Dysfunction in fatty acid amide hydrolase is associated with depressive-like behavior in Wistar Kyoto rats |
Overall design | The role of the endocannabinoid (eCB) system in depressive behavior was examined in Wistar Kyoto (WKY) rat strain, a genetic model of depression. For basal comparison, WKY rats (WKY group) and the control WIS rats (WIS group) were euthanized and brain regions (frontal cortex and hippocampus) were dissected. Brain regions were used for the analysis of AEA. Then antidepressant-like property of URB597 was evaluated using the forced-swim test. WKY rats were treated with FAAH inhibitor, URB597 (0.3 mg/kg body, i.p.) once daily in the morning (10 AM) for 7 days (WKY + URB597 group). The control WKY rats received vehicle (WKY + vehicle group). Levels of eCB, AEA, were determined using liquid chromatography mass spectroscopy (LC-MS). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 21 |
Tissue | Central; Brain; Frontal cortex; Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Vinod KY, Xie S, Psychoyos D, et al. Dysfunction in fatty acid amide hydrolase is associated with depressive-like behavior in Wistar Kyoto rats. PLoS One. 2012;7(5):e36743. |
Metabolite |
