Study M504
Study name | Guida F 2018 |
Title | Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice |
Overall design | The aim of this study was to examine the behavioural, biochemical and electrophysiological alterations, as well as gut microbiota composition in a model of antibiotic-induced experimental dysbiosis. C57BL/6 mice were treated with Ampicillin, Streptomycin and Clindamycin (ASC) in the drinking water (Dysbiotic group) or sterile water only (0-14 days) (control group). Afterwards, they were treated with probiotic or saline via gavage (14-21 days). N-acylserotonin, N-acylethanolamine and endocannabinoid levels in jejunum, ileum and duodenum were measured. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Mouse; C57/BL6 mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Tail suspension test, forced swimming test |
Sample size | 40 |
Tissue | Peripheral; Gut; Ileum; Peripheral; Gut; Duodenum; Peripheral; Gut; Jejunum; |
Platform | MS-based; LC-MS: LC20AB with hybrid detector IT-TOF (Shimadzu Corporation, Kyoto, Japan); |
PMID | |
DOI | |
Citation | Guida F, Turco F, Iannotta M, et al. Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice. Brain Behav Immun. 2018;67:230-45. |
Metabolite |
