Study M499
Study name | Hill MN 2008c |
Title | Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents |
Overall design | The aim of this study was to examine whether the endocannabinoid system is altered by chronic antidepressant treatment. Rats were divided into the following 3 groups: (1) control group (0.9% saline), (2) tranylcypromine group (tranylcypromine treatment at the dose of 10 mg/kg), and (3) fluoxetine group (fluoxetine treatment at the dose of 5 mg/kg. Drugs were daily intraperitoneal injecteds for 21 days. For analysis of endocannabinoid content, brain regions were subjected to a lipid extraction process. The content of the two primary endocannabinoids, anandamide and 2-arachidonylglycerol, within lipid extracts was determined using isotope-dilution liquid chromatography mass spectrometry. |
Study Type | Type3; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Not reported |
Sample size | 25 |
Tissue | Central; Brain; Prefrontal cortex; Central; Brain; Hippocampus; Central; Brain; Hypothalamus; |
Platform | MS-based; LC-MS: not reported; |
PMID | |
DOI | |
Citation | Hill MN, Ho WS, Hillard CJ, et al. Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents. J Neural Transm. 2008;115(12):1673-9. |
Metabolite |
