Study M494
Study name | Nasca C 2018 |
Title | Acetyl-l-carnitine deficiency in patients with major depressive disorder |
Overall design | In this study, the role of acetyl-l-carnitine (LAC) in major depressive disorder (MDD) in humans was evaluated using a biological target- and mechanistically driven approach. In a sample of 116 participants, including healthy control (control group, n = 45) and patients with MDD (depression group, n = 71), LAC levels in plasma were measured by UPLC-MS/MS and ESI-MS/MS. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 116 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: TQD tandem mass spectrometer with Acquity UPLC system (Waters Corp.); |
PMID | |
DOI | |
Citation | Nasca C, Bigio B, Lee FS, et al. Acetyl-l-carnitine deficiency in patients with major depressive disorder. Proc Natl Acad Sci U S A. 2018;115(34):8627-32. |
Metabolite |
