Study M491
Study name | Yoo CH 2018b |
Title | Investigating the metabolic alterations in a depressive-like rat model of chronic forced swim stress: an in vivo proton magnetic resonance spectroscopy study at 7T |
Overall design | The purpose of this study was to investigate the in vivo effects of CFSS on systems other than the monoamine system in the rat prefrontal cortex (PFC) with 7T and short-echo-time (16.3 ms) proton magnetic resonance spectroscopy (1H MRS). Ten male Wistar rats underwent 14 days of chronic forced swim stress (CFSS), and in vivo 1H MRS and forced swim tests were performed before and after CFSS. Point-resolved spectroscopy was used to quantify metabolite levels in the rat PFC. To investigate spectral overlap in glutamate and glutamine, spectral analyses in the spectra obtained in the in vivo1H MRS, parametrically matched spectral simulation, and in vitro experiments were performed. Metabolite quantification was reported in absolute concentrations. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test |
Sample size | 10 |
Tissue | Central; Brain; Prefrontal cortex; |
Platform | MRS; MRS: Bruker PharmaScan 7T MRI system (Bruker BioSpin Corporation, Billerica, MA, USA); |
PMID | |
DOI | |
Citation | Yoo CH, Lim SI, Song KH, et al. Investigating the metabolic alterations in a depressive-like rat model of chronic forced swim stress: an in vivo proton magnetic resonance spectroscopy study at 7T. Neurochem Int. 2018;116:22-9. |
Metabolite | myo-Inositol; N-Acetyl-L-aspartic acid; Choline-containing compounds; |
