Study M488
Study name | Wise T 2018 |
Title | Glutamatergic hypofunction in medication-free major depression: secondary effects of affective diagnosis and relationship to peripheral glutaminase |
Overall design | In this study, the authors measured levels of glutamate in the dorsal anterior cingulate cortex in-vivo using 1H-Magnetic Resonance Spectroscopy in medication free unipolar and bipolar patients (n=29, 20 unipolar and 9 bipolar) experiencing a major depressive episode, in comparison with a group of matched healthy controls (n=20). The authors also analysed peripheral glutaminase measured in serum to examine the relationship between central and peripheral measures. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, MADRS >= 18 |
Sample size | 40 |
Tissue | Central; Brain; Dorsal anterior cingulate cortex; |
Platform | MRS; MRS: GE MR-750 3 T system; |
PMID | |
DOI | |
Citation | Wise T, Taylor MJ, Herane-Vives A, et al. Glutamatergic hypofunction in medication-free major depression: secondary effects of affective diagnosis and relationship to peripheral glutaminase. J Affect Disord. 2018;234:214-9. |
Metabolite |
