Study M485
Study name | Tang YY 2018 |
Title | Elevated hippocampal choline level is associated with altered functional connectivity in females with major depressive disorder: a pilot study |
Overall design | The present pilot study combined magnetic resonance spectroscopy (MRS) and resting-state functional magnetic resonance imaging (rs-fMRI) to investigate the hippocampal metabolic alteration and its relationship with the intrinsic functional connectivity (FC) changes in major depressive disorder (MDD). Both MRS and fMRI data were obtained from twelve women with MDD (depression group) and twelve age-matched, healthy women (control group). Bilateral hippocampi were chosen as regions of interest, in which metabolite concentrations of total choline (tCho), N-acetylaspartate and creatine were quantified. Bilateral hippocampal FC to the whole brain and its correlations with hippocampal metabolite concentrations were conducted. Metabolite quantification was reported in absolute concentrations. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | ICD-10 diagnosed MDD |
Sample size | 24 |
Tissue | Central; Brain; Hippocampus; |
Platform | MRS; MRS: Siemens 3.0-T Verio MRI scanner (MR B17, Siemens AG, Erlangen, Germany); |
PMID | |
DOI | |
Citation | Tang Y, Zhang X, Sheng J, et al. Elevated hippocampal choline level is associated with altered functional connectivity in females with major depressive disorder: a pilot study. Psychiatry Res Neuroimaging. 2018:S0925-4927(17)30297-4. |
Metabolite |
