Study M484
Study name | Tang CZ 2019 |
Title | Up-regulated miR-192-5p expression rescues cognitive impairment and restores neural function in mice with depression via the Fbln2-mediated TGF-beta1 signaling pathway |
Overall design | In this study, the hippocampal cAMP level in the chronic unpredictable mild stress (CUMS) model of depression was investigated by LC-MS. C57BL/6 mice were divided into the following 2 groups: (1) control group, and (2) CUMS group. The CUMS stress procedure lasted for 4 weeks. Ten samples per group were used for LC-MS analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Tail suspension test |
Sample size | 20 |
Tissue | Central; Brain; Hippocampus; |
Platform | MS-based; LC-MS: LC-20A DXR ultra-fast liquid chromatography system (Shimadzu, Kyoto, Japan) with Sciex API 4000 QTrap Mass Spectrometer (Thermo Fisher Scientific, Waltham, MA, USA); |
PMID | |
DOI | |
Citation | Tang CZ, Yang JT, Liu QH, et al. Up-regulated miR-192-5p expression rescues cognitive impairment and restores neural function in mice with depression via the Fbln2-mediated TGF-beta1 signaling pathway. FASEB J. 2019;33(1):606-618. |
Metabolite |
