Study M480
Study name | Ma WN 2018 |
Title | Urinary metabolomic study of chlorogenic acid in a rat model of chronic sleep deprivation using gas chromatography-mass spectrometry |
Overall design | The urinary metabolomic study based on gas chromatography-mass spectrometry (GC-MS) had been developed to investigate the possible antidepressant mechanism of chlorogenic acid (CGA) in a rat model of sleep deprivation (SD). The rats were randomly divided into three groups (n = 6 each): (1) control group (big platform group), (2) sleep deprivation group (small platform group also known as sleep deprivation group), and (3) CGA-treated group (sleep deprivation with chlorogenic acid treatment at a daily dose of 50 mg/kg of body weight, orally). At the end of the SD paradigm, rats were subjected to forced swimming test and tail suspension test. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 18 |
Tissue | Peripheral; Urine; Urine; |
Platform | MS-based; GC-MS: Agilent 6890/5975B GC/MSD system (Agilent Technologies, California, USA); |
PMID | |
DOI | |
Citation | Ma WN, Zhou MM, Gou XJ, et al. Urinary metabolomic study of chlorogenic acid in a rat model of chronic sleep deprivation using gas chromatography-mass spectrometry. Int J Genomics. 2018;1361402. |
Metabolite | Citric acid; Glycine; L-Lactic acid; L-Alanine; L-Asparagine; L-Lysine; Hippuric acid; Suberic acid; 5-Hydroxyindoleacetic acid; D-Fructose; Azelaic acid; Threonic acid; Creatinine; Uric acid; Ascorbic acid; Uracil; Niacinamide; Glycolic acid; 2-Hydroxyglutarate; 4-Deoxyerythronic acid; Nicotinic acid; D-Mannose; Putrescine; Pipecolic acid; Phenylacetic acid; D-Arabitol; 2-Ethylhydracrylic acid; Protocatechuic acid; 3,4-Dihydroxyhydrocinnamic acid; 2,4-Dihydroxybutanoic acid; |
