Study M476
Study name | Jiang HX 2019 |
Title | Inhibition of fatty acid amide hydrolase improves depressive-like behaviors independent of its peripheral antinociceptive effects in a rat model of neuropathic pain |
Overall design | Adult male Wistar rats with chronic constriction injury (CCI) to the sciatic nerve were treated with the systemic fatty acid amide hydrolase (FAAH) inhibitor URB597 (5.8 mgxkgxday, intraperitoneally) or peripherally acting FAAH inhibitor URB937 (1.6 mg/kg/d, intraperitoneally; n = 11-12). The treatment was applied from the 15th day after surgery and continued for 15 days. Mechanical withdrawal threshold was examined by Von Frey test before surgery and on the 28th day after CCI. Depressive-like behaviors were evaluated by forced swimming test (FST) and novelty-suppressed feeding (NSF) after 15-day treatment. The levels of anandamide and 2-arachidonoylglycerol in hippocampus were examined by liquid chromatography and mass spectrometry (n = 6 animals per group). |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test |
Sample size | 36 |
Tissue | Central; Brain; Hippocampus; Peripheral; Blood; Serum; |
Platform | MS-based; LC-MS: Agilent 1260 liquid chromatograph with 6460 triple quadrupole mass spectrometer; |
PMID | |
DOI | |
Citation | Jiang HX, Ke BW, Liu J, et al. Inhibition of fatty acid amide hydrolase improves depressive-like behaviors independent of its peripheral antinociceptive effects in a rat model of neuropathic pain. Anesth Analg. 2019 Aug;129(2):587-597. |
Metabolite |
