Study M465

Study name

Abdallah CG 2018

Title

The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects

Overall design

The aim of this study was to determine ketamine’s effect on glutamate-glutamine cycling and to investigate the association between changes in neurotransmission and the psychotomimetic effects of ketamine. Twenty-one participants (14 healthy and 7 depressed) completed two 13C MRS scans during infusion of normal saline or subanesthetic doses of ketamine.

Study Type

Type2;

Type3;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Healthy individuals; Healthy individuals; Healthy individuals;

Criteria for depression

Structured interview diagnosed MDD, MADRS >= 18

Sample size

21

Tissue

Central; Brain; Prefrontal lobe;

Platform

MRS; MRS: 4.0 T whole-body magnet interfaced to a Bruker AVANCE spectrometer (Bruker Instruments, Billerica, MA, USA);

PMID

29977074

DOI

10.1038/s41386-018-0136-3

Citation

Abdallah CG, De Feyter HM, Averill LA, et al. The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects. Neuropsychopharmacology 2018;43(10):2154-60.

Metabolite

L-Glutamine;