Study M453
Study name | Godlewska BR 2017 |
Title | Brain glutamate in medication-free depressed patients: a proton MRS study at 7 Tesla |
Overall design | The aim of the present study was to use magnetic resonance spectroscopy (MRS) at 7 T to assess levels of glutamate and glutamine in un-medicated depressed patients (depression group, n = 55), and age and gender-matched controls (control group, n = 50), in three brain regions, anterior cingulate cortex (ACC), occipital cortex (OCC) and putamen (PUT). Neurometabolites were calculated using the unsuppressed water signal as a reference. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | An episode of major depression |
Sample size | 105 |
Tissue | Central; Brain; Occipital cortex; Central; Brain; Putamen; Central; Brain; Anterior cingulate cortex; |
Platform | MRS; MRS: 7 T Siemens MAGNETOM scanner (Siemens, Erlangen, Germany); |
PMID | |
DOI | |
Citation | Godlewska BR, Masaki C, Sharpley AL, et al. Brain glutamate in medication-free depressed patients: a proton MRS study at 7 Tesla. Psychol Med 2017. |
Metabolite |
