Study M449
Study name | Zhang L 2017 |
Title | Correlation between cerebellar metabolism and post-stroke depression in patients with ischemic stroke |
Overall design | The aim of this study was to explore the correlation between cerebellar metabolism changes and post-stroke depression (PSD) using proton magnetic resonance spectroscopy (1H-MRS). Participants were assigned to 3 groups: 60 patients with PSD (PSD group), 60 stroke patients without depression (NOPSD group), and 60 healthy volunteers (control group). T1 WI, T2 WI, DWI and 1H-MRS examination were performed for patients at 14 days, 3 months after the stroke, respectively, and for healthy volunteers once when included in the study. Metabolite quantification was reported relative as ratios. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Post-stroke depression; Post-stroke depression; |
Criteria for depression | CCMD-3 diagnosed MDD, Self-rating Depression Scale >= 53, HAMD-17 > 7 |
Sample size | 180 |
Tissue | Central; Brain; Cerebellum; |
Platform | MRS; MRS: 3T high-field magnetic resonance (GE Medical Systems); |
PMID | |
DOI | |
Citation | Zhang L, Li M, Sui R. Correlation between cerebellar metabolism and post-stroke depression in patients with ischemic stroke. Oncotarget 2017;8(53):91711-22. |
Metabolite | Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
