Study M367
Study name | Fonseca R 2017 |
Title | Methamphetamine induces anhedonic-like behavior and impairs frontal cortical energetics in mice |
Overall design | The aim of this study was to characterize frontal cortical metabolic alterations associated with early negative mood behavior triggered by methamphetamine (METH). Adult C57BL/6 mice were injected with METH, and their frontal cortical metabolic status was characterized after probing their mood and anxiety-related phenotypes 3 days post-injection. Mice were divided into the following 2 groups (n = 24 in each group): (1) control group, (2) METH group (methamphetamine administration at the single dose of 30 mg/kg, i.p.). Metabolite quantification was performed using NMR. Six mice in control group and eight mice in METH group were used for metabonomic analysis. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Mouse; C57BL/6 mouse; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Sucrose preference test |
Sample size | 14 |
Tissue | Central; Brain; Frontal cortex; |
Platform | MRS; MRS: 500-MHz Brucker NMR spectrometer; |
PMID | |
DOI | |
Citation | Fonseca R, Carvalho RA, Lemos C, et al. Methamphetamine induces anhedonic-like behavior and impairs frontal cortical energetics in mice. CNS Neurosci Ther 2017;23(2):119-26. |
Metabolite |
