Study M366
Study name | Khan AR 2018 |
Title | Diffusion MRI and MR spectroscopy reveal microstructural and metabolic brain alterations in chronic mild stress exposed rats: a CMS recovery study |
Overall design | The present study aims to explore microstructural and metabolic alterations using diffusion MRI (d-MRI) and 1H magnetic resonance spectroscopy (1H MRS) in a group of rats exposed to unpredictable chronic mild stress (CMS) exposure for eight weeks. Rats were divided into the following 2 groups: (1) control group, (2) CMS group (chronic mild stress for 8 weeks). Based on the sucrose consumption test, CMS exposed animals were further identified as anhedonic or resilient. A group of (n = 8) animals were identified as anhedonic, and an unexposed age-match group was included as control (n = 8). Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Long-Evans rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 16 |
Tissue | Central; Brain; Ventral hippocampus; |
Platform | MRS; MRS: 9.4 T Bruker Biospec preclinical MRI system (Bruker Biospin, Ettlingen, Germany); |
PMID | |
DOI | |
Citation | Khan AR, Hansen B, Wiborg O, et al. Diffusion MRI and MR spectroscopy reveal microstructural and metabolic brain alterations in chronic mild stress exposed rats: a CMS recovery study. Neuroimage 2017;167:342-53. |
Metabolite |
