Study M365
Study name | Shan YY 2017 |
Title | Correlations between working memory impairment and neurometabolites of prefrontal cortex and lenticular nucleus in patients with major depressive disorder |
Overall design | The aim of this study was to find out the mechanism by using neuropsychological tests and proton magnetic resonance spectroscopy (1H-MRS). Major depressive disorder (MDD) patients (depression group, n = 31) and healthy controls (control group, n = 31) were recruited in our study. The working memory performance and neurometabolite ratios of prefrontal cortex (PFC) and lenticular nucleus (LN) between two groups were evaluated and compared. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-V diagnosed MDD, HAMD-24 >= 20 |
Sample size | 62 |
Tissue | Central; Brain; Lenticular nucleus; Central; Brain; Prefrontal cortex; |
Platform | MRS; MRS: Discovery MR 750 3.0T MRI scanner (General Electric, Milwaukee, WI, USA); |
PMID | |
DOI | |
Citation | Shan Y, Jia Y, Zhong S, et al. Correlations between working memory impairment and neurometabolites of prefrontal cortex and lenticular nucleus in patients with major depressive disorder. J Affect Disord 2017;227:236-42. |
Metabolite |
