Study name | Freed RD 2017 |
Title | A pilot study of cortical glutathione in youth with depression |
Overall design | This study used proton magnetic resonance spectroscopy (1H MRS) to measure in vivo brain glutathione (GSH) in adolescents with major depressive disorder (MDD), and explored the relationship between GSH and illness severity and chronicity. Secondarily, associations between GSH and anhedonia, a key symptom of MDD in adolescents, were investigated. Occipital cortex GSH levels were obtained in psychotropic medication-free adolescents with MDD (depression group, n = 19) and compared to those in healthy control adolescents (control group, n = 8). Metabolite quantification was reported relative to brain water concentration. |
Type1; | |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Pediatric depression; Pediatric depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 27 |
Tissue | Central; Brain; Occipital cortex; |
Platform | MRS; MRS: 3.0 T GE MR system; |
PMID | |
DOI | |
Citation | Freed RD, Hollenhorst CN, Weiduschat N, et al. A pilot study of cortical glutathione in youth with depression. Psychiatry Res 2017;270:54-60. |
Metabolite |