Study M364

Study name

Freed RD 2017

Title

A pilot study of cortical glutathione in youth with depression

Overall design

This study used proton magnetic resonance spectroscopy (1H MRS) to measure in vivo brain glutathione (GSH) in adolescents with major depressive disorder (MDD), and explored the relationship between GSH and illness severity and chronicity. Secondarily, associations between GSH and anhedonia, a key symptom of MDD in adolescents, were investigated. Occipital cortex GSH levels were obtained in psychotropic medication-free adolescents with MDD (depression group, n = 19) and compared to those in healthy control adolescents (control group, n = 8). Metabolite quantification was reported relative to brain water concentration.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Pediatric depression; Pediatric depression;

Criteria for depression

DSM-IV diagnosed MDD

Sample size

27

Tissue

Central; Brain; Occipital cortex;

Platform

MRS; MRS: 3.0 T GE MR system;

PMID

29078101

DOI

10.1016/j.pscychresns.2017.10.001

Citation

Freed RD, Hollenhorst CN, Weiduschat N, et al. A pilot study of cortical glutathione in youth with depression. Psychiatry Res 2017;270:54-60.

Metabolite

Glutathione;