Study M363
Study name | Cano M 2017 |
Title | Brain volumetric and metabolic correlates of electroconvulsive therapy for treatment-resistant depression: a longitudinal neuroimaging study |
Overall design | The aim of this study was to assess longitudinal changes in (i) regional gray matter (GM) volumes and (ii) hippocampal metabolite concentrations throughout an acute course of bitemporal electroconvulsive therapy (ECT), as well as (iii) to determine the association between imaging changes and clinical improvement. Patients with treatment-resistant depression (TRD) (depression group, n = 12) were assessed at four time points (pre-treatment, after the first ECT session, after the ninth ECT session and 15 days after ECT course completion) and healthy participants (control group, n = 10) at two time points, 5 weeks apart. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Treatment-resistant depression; Treatment-resistant depression; |
Criteria for depression | DSM-IV-TR diagnosed MDD |
Sample size | 22 |
Tissue | Central; Brain; Hippocampus; |
Platform | MRS; MRS: Philips Achieva 3.0 Tesla magnet scanner (Philips Healthcare, Best, The Netherlands); |
PMID | |
DOI | |
Citation | Cano M, Martínez-Zalacain I, Bernabeu-Sanz A, et al. Brain volumetric and metabolic correlates of electroconvulsive therapy for treatment-resistant depression: a longitudinal neuroimaging study. Transl Psychiatry 2017;7(2):e1023. |
Metabolite |
