Study M360
Study name | Granados-Dominguez LM 2013 |
Title | Increased myo-inositol in the posterior cingulate cortex in first-episode major depressive patients |
Overall design | The aim of this study was to use proton magnetic resonance spectroscopy (MRS) as a means of analyzing brain metabolites in the posterior cingulate cortex (PCC) of a group of first-episode, unmedicated major depressive disorder (MDD) patients. PCC metabolite levels were analyzed at 3-T in a single voxel located bilaterally over the PCC in patients diagnosed for the first time with MDD (depression group, n = 7) and with no previous pharmacological treatment, as well as in control subjects (control group, n = 9). Differences in metabolite levels between groups were compared. Metabolite quantification was reported in absolute concentrations. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 > 14, BDI > 10 |
Sample size | 16 |
Tissue | Central; Brain; Posterior cingulate cortex; |
Platform | MRS; MRS: 3.0 Tesla MR scanner Achieva Quasar Dual MRI System (Phillips Medical Systems, Eindhove, Holland); |
PMID | |
DOI | |
Citation | Granados-Dominguez LM, Flores-Gutierrez EO, Alcauter S, et al. Increased myo-inositol in the posterior cingulate cortex in first-episode major depressive patients. Advances in Bioscience and Biotechnology 2013;4(6A):45-52. |
Metabolite | myo-Inositol; myo-Inositol/Creatine ratio; (N-Acetyl aspartate and N-Acetylglutamic acid)/Creatine ratio; |
