Study M359
Study name | Zhang JJ 2013 |
Title | Glutamate normalization with ECT treatment response in major depression |
Overall design | To identify treatment-related changes in neurochemical markers implicated in major depressive disorder (MDD), single-voxel proton magnetic resonance spectroscopy (1HMRS) was applied for cross-sectional and longitudinal analysis of anterior cingulate cortex (ACC) glutamate (Glu), choline (Cho) and N-acetyl aspartate (NAA) in patients with (depression group, n = 10), followed prospectively during index treatment, and demographically similar controls (control group, n = 10). Patients were assessed at three time points, prior to their first ECT (baseline) and after their 2nd and 6th ECT sessions, corresponding to approximately 48 hrs and 2 weeks following treatment onset. Metabolite quantification was reported in arbitrary units. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV-TR diagnosed MDD, HAMD-17 >= 18, MADRS >= 20 |
Sample size | 20 |
Tissue | Central; Brain; Anterior cingulate cortex; |
Platform | MRS; MRS: Siemens 3T Allegra system; |
PMID | |
DOI | |
Citation | Zhang J, Narr KL, Woods RP, et al. Glutamate normalization with ECT treatment response in major depression. Mol Psychiatry 2013;18(3):268-70. |
Metabolite |
