Study M358
Study name | Taylor M 2008 |
Title | Differential effects of citalopram and reboxetine on cortical Glx measured with proton MR spectroscopy |
Overall design | The aim of the present study was to use proton magnetic resonance spectroscopy (MRS) to assess the effects of short-term administration of the selective serotonin re-uptake inhibitor, citalopram and the selective noradrenaline re-uptake inhibitor, reboxetine, on a composite measure of glutamate and glutamine (Glx) in occipital cortex in healthy volunteers using a parallel group, placebo-controlled design. Thirty healthy volunteers were randomly allocated to 7-10 days treatment with the following treatments in a double-blind parallel group design: (1) placebo group (placebo treatment, n = 8), (2) citalopram group (citalopram 20 mg daily treatment, n = 11), and (3) reboxetine group (reboxetine 8 mg daily treatment, n = 11). The tissue content of Glx and GABA were referenced to creatine (Glx:Cr and GABA:Cr). |
Study Type | Type3; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Not reported |
Sample size | 30 |
Tissue | Central; Brain; Occipital cortex; |
Platform | MRS; MRS: 3 Tesla Varian INOVA system (Varian Inc, Palo Alto, CA, USA); |
PMID | |
DOI | |
Citation | Taylor M, Murphy SE, Selvaraj S, et al. Differential effects of citalopram and reboxetine on cortical Glx measured with proton MR spectroscopy. J Psychopharmacol 2008;22(5):473-6. |
Metabolite | (Glutamate and Glutamine)/(Creatine and Phosphocreatine) ratio; |
