Study M357

Study name

MacMaster FP 2008

Title

Medial temporal N-acetyl-aspartate in pediatric major depression

Overall design

The aim of this study is to determine if hippocampal neuronal viability, as represented by medial temporal cortex (MTC) N-acetyl-aspartate (NAA) concentrations, is impaired in pediatric treatment-naive major depressive disorder (MDD) as compared with healthy control children. Treatment-naive pediatric outpatients with MDD (depression group, n = 11) and healthy subjects (control group, n = 11) were case-control matched. Magnetic resonance spectroscopic (MRS) examination of MTC was conducted. Data were collected on absolute NAA, choline compounds (Cho) and creatine/phosphocreatine (Cr). Data are reported in institutional units.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Pediatric depression; Pediatric depression;

Criteria for depression

DSM-IV diagnosed MDD

Sample size

22

Tissue

Central; Brain; Medial temporal cortex;

Platform

MRS; MRS: 1.5 T Signa scanning system (General Electric, Milwaukee, WI);

PMID

18703320

DOI

10.1016/j.pscychresns.2007.12.022

Citation

MacMaster FP, Moore GJ, Russell A, et al. Medial temporal N-acetyl-aspartate in pediatric major depression. Psychiatry Res 2008;164(1):86-9.

Metabolite

N-Acetyl-L-aspartic acid;