Study M356

Study name

Nam YY 2005

Title

[Effects of mirtazapine on hippocampal metabolites of female patients with major depression]

Overall design

The aim of this study was to investigate whether mirtazapine treatment has the neurotrophic effects in depressed patient by using 1H-MRS and explored the relationship between these effects and clinical improvements and neuropsychological functions. Female patients with major depressive disorder (depression group, n = 14) and healthy controls (control group, n = 12) participated in the study. Before the treatment with mirtazapine, the authors measured severity of illness, neuropsychological functions, and the levels of NAA, Cho and Cr in both hippocampi using 1H-MRS in the depressed subjects. After the treatment with mirtazapine for 6 weeks (between 15 and 45 mg daily), the measures of the pretreatment condition were repeated in the depressed subjects. Metabolite quantification was reported relative to total creatine as the reference peak.

Study Type

Type1;

Type2;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD, HAMD-17 >= 19

Sample size

26

Tissue

Central; Brain; Hippocampus;

Platform

MRS; MRS: 1.5 Tesla proton magnetic resonance spectroscopy (Gyroscan, Phillips Medical System, Best, Netherlands);

PMID

N/A

DOI

N/A

Citation

Nam YY, Kim CH, Lee SK, et al. [Effects of mirtazapine on hippocampal metabolites of female patients with major depression]. Korean J Psychopharmacol 2005;16(2):146-55. (Article in Korean)

Metabolite

Choline-containing compounds/(Creatine and Phosphocreatine) ratio;