Study M355
Study name | van der Hart MG 2002 |
Title | Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume |
Overall design | The present study investigated the effect of the NK1R antagonist L-760,735 and the tricyclic antidepressant clomipramine in the chronic psychosocial stress paradigm of adult male tree shrews. Animals were divided into the following 4 groups: (1) control group, (2) stress group (daily psychosocial conflict stress), (3) stress + L-760,735 group (daily psychosocial conflict stress plus L-760,735 treatment at the dose of 10 mg/kg), and (4) stress + clomipramine group (daily psychosocial conflict stress plus clomipramine treatment at the dose of 50 mg/kg). The psychosocial conflict stress procedure lasted for 5 weeks, and drugs were administered via tap water during the last 4 weeks of the model building period. Brain metabolite concentrations were determined in vivo by proton magnetic resonance spectroscopy. Sample sizes were 9 for control group, 11 for stress group, 5 for stress + clomipramine group and 5 for stress + L-760,735 group. Metabolite quantification was reported relative to brain water concentration. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Non-human primate; Tree shrew; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Not reported |
Sample size | 30 |
Tissue | Central; Brain; Brain; |
Platform | MRS; MRS: 2.35 T MRBR 4.7/400 mm magnet (Magnex Scientific, Abingdon, England); |
PMID | |
DOI | |
Citation | van der Hart MG, Czeh B, de Biurrun G, et al. Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume. Mol Psychiatry 2002;7(9):933-41. |
Metabolite |
