Study M354
Study name | Mervaala E 2000 |
Title | Quantitative MRI of the hippocampus and amygdala in severe depression |
Overall design | The aim of this study was to find possible structural changes in the amygdala and hippocampus of patients with severe depression. Quantitative MRI of the amygdala and hippocampus, as well as proton spectroscopy (MRS) of mesial temporal structures were studied in drug-resistant in-patients with major depression (depression group, n = 28 for MRS) and compared with age-matched controls (control group, n = 12 for MRS). Six patients had bipolar and 28 monopolar depression. All patients were referred for ECT due to a life-threatening depression induced by resistance to either drugs or psychotherapy. The chemical shifts were referenced to Nacetylaspartate (NAA). The metabolite intensity ratios were also calculated for NAA/creatine, NAA/choline, and choline/creatine. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Treatment-resistant depression; Treatment-resistant depression; |
Criteria for depression | DSM-III-R diagnosed severe major depression |
Sample size | 40 |
Tissue | Central; Brain; Mesial temporal lobe; |
Platform | MRS; MRS: 1.5 T Magnetom (Siemens, Erlangen); |
PMID | |
DOI | |
Citation | Mervaala E, Fohr J, Kononen M, et al. Quantitative MRI of the hippocampus and amygdala in severe depression. Psychol Med 2000;30(1):117-25. |
Metabolite | Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
