Study M351

Study name

Mu J 2007b

Title

[1H-MRS study of thalamus in patients with the first episode depression]

Overall design

The aim of this study was to explore the existence of thalamus metabolic change in drug naive patients with first episode depression. Drug naive patients with first episode depression (depression group, n = 20) and age-matched controls (control group, n = 20) were scanned for N-acetyl-aspartate (NAA), glutamate and glutamine (Glx), choline-containing compounds (Cho), creatine and phosphocreatine (Cr) by 1H-MRS. Metabolite quantification was reported relative to total creatine as the reference peak.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD

Sample size

40

Tissue

Central; Brain; Thalamus;

Platform

MRS; MRS: 1.5 T GE Signa Highspeed Superconductive Imaging System (General Electric Medical Systems);

PMID

N/A

DOI

10.3969/j.issn.1002-0152.2007.04.008

Citation

Mu J, Xie P, Yang ZS, et al. [1H-MRS study of thalamus in patients with the first episode depression]. Chinese Journal of Nervous & Mental Diseases 2007;33(4):229-32. (Article in Chinese)

Metabolite

N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio;