Study M349
Study name | Lefebvre D 2017 |
Title | A pilot study of hippocampal N-acetyl-aspartate in youth with treatment resistant major depression |
Overall design | The aim of this study was to investigated the relationship between hippocampal N-acetylaspartate (NAA) and glutamate concentrations as well as hippocampal volume with depressive symptoms in youth with treatment resistant depression (TRD). Typically developing youth (control group, n = 15) and youth with TRD (depression group, n = 18) underwent 1H-MRS and MRI on a 3 T scanner. A short echo PRESS protocol was used with voxels in the right and left hippocampi (6mL each). Hippocampal volume was evaluated using FreeSurfer. Metabolite quantification was reported in absolute concentrations. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Treatment-resistant depression; Treatment-resistant depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 33 |
Tissue | Central; Brain; Hippocampus; |
Platform | MRS; MRS: General Electric Healthcare Discovery MR750w 3.0 T scanner; |
PMID | |
DOI | |
Citation | Lefebvre D, Langevin LM, Jaworska N, et al. A pilot study of hippocampal N-acetyl-aspartate in youth with treatment resistant major depression. J Affect Disord 2017;207:110-3. |
Metabolite |
