Study name | Harper DG 2017 |
Title | Tissue type-specific bioenergetic abnormalities in adults with major depression |
Overall design | This study performed a phosphorus-31 magnetic resonance spectroscopy (31P MRS) study measuring the energetic metabolites beta-NTP (the beta-phosphate is the unique signature of NTP), phosphocreatine (PCr), and phosphate (Pi) at a 4-Tesla magnetic field strength comparing adult major depressive disorder (MDD) subjects with healthy volunteers. This study recruited subjects with a current diagnosis of MDD, not currently treated with psychotropic medication (depression group, n = 50), and healthy volunteers, matched for age and gender (control group, n = 30). All subjects received a T1 MP-FLASH scan for tissue segmentation followed by 31P MRS, chemical shift imaging scan with 84 voxels of data collected over the entire brain utilizing a dual-tuned, proton-phosphorus coil to minimize subject movement. Phosphocreatine and inorganic phosphate (Pi) varied in opposite directions across gray matter and white matter when MDD subjects were compared with controls. For metabolite quantification, the peak area was normalized by the total phosphorous signal. |
Type1; | |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 >= 16 |
Sample size | 80 |
Tissue | Central; Brain; White matter; Central; Brain; Gray matter; |
Platform | MRS; MRS: 4-Tesla MR; |
PMID | |
DOI | |
Citation | Harper DG, Jensen JE, Ravichandran C, et al. Tissue type-specific bioenergetic abnormalities in adults with major depression. Neuropsychopharmacology 2017;42(4):876-85. |
Metabolite |