Study M346
Study name | Rosa CE 2017 |
Title | Glutamatergic and neural dysfunction in postpartum depression using magnetic resonance spectroscopy |
Overall design | This study aimed to evaluate brain metabolites abnormalities in women with postpartum depression (PPD) compared with healthy postpartum women. Postpartum depression patients (depression group, n = 33) and healthy postpartum women (control group, n = 25) underwent a proton magnetic resonance spectroscopy (1H-MRS) acquired on a 3-T MRI system, with the volume of interest positioned in anterior cingulate gyrus (ACG) and dorsolateral prefrontal (DLPF). An ANCOVA was conducted with age, postpartum time, and contraceptive type as covariates. Metabolite quantification was reported in absolute concentrations. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Postpartum depression; Postpartum depression; |
Criteria for depression | DSM-IV-TR diagnosed MDD |
Sample size | 58 |
Tissue | Central; Brain; Anterior cingulate gyrus; Central; Brain; Dorsolateral prefrontal; |
Platform | MRS; MRS: 3 T magnetic resonance scanner (Philips, Achieva, The Netherlands); |
PMID | |
DOI | |
Citation | Rosa CE, Soares JC, Figueiredo FP, et al. Glutamatergic and neural dysfunction in postpartum depression using magnetic resonance spectroscopy. Psychiatry Res 2017;265:18-25. |
Metabolite |
