Study M345
Study name | Robillard R 2017 |
Title | Lower in vivo myo-inositol in the anterior cingulate cortex correlates with delayed melatonin rhythms in young persons with depression |
Overall design | This study examined associations between myo-inositol in the anterior cingulate cortex and the timing of evening melatonin release. Young persons with unipolar depression were recruited from specialized mental health services (depression group, n = 40). Healthy controls were recruited from the community (control group, n = 40). The timing of dim light melatonin onset (DLMO) was estimated using salivary melatonin sampling. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV-TR diagnosed MDD |
Sample size | 80 |
Tissue | Central; Brain; Anterior cingulate cortex; |
Platform | MRS; MRS: 3-Tesla GE Discovery MR750 scanner (GE Medical Systems, Milwaukee, WI); |
PMID | |
DOI | |
Citation | Robillard R, Lagopoulos J, Hermens DF, et al. Lower in vivo myo-inositol in the anterior cingulate cortex correlates with delayed melatonin rhythms in young persons with depression. Front Neurosci 2017;11:336. |
Metabolite |
