Study M344
Study name | Njau S 2017 |
Title | Neurochemical correlates of rapid treatment response to electroconvulsive therapy in patients with major depression |
Overall design | The aim of this study was to examine proton magnetic resonance spectroscopy (1H-MRS)-derived changes in neurochemistry underlying Electroconvulsive therapy (ECT) treatment and ECT-related clinical response and to establish whether metabolite levels measured before ECT predict subsequent treatment outcome. 1H-MRS was used to measure longitudinal changes in glutamate/glutamine (Glx), creatine (Cre), choline (Cho) and N-acetylaspartate (NAA) in the dorsal (dACC) and subgenual anterior cingulate cortex (sgACC) and bilateral hippocampus in patients receiving ECT scanned at baseline, after the second ECT session and after the ECT treatment series. Patients were compared with demographically similar controls at baseline. Controls were assessed twice to establish normative values and variance. Fifty patients (depression group, 43 with unipolar, 7 with bipolar depression) and 33 controls (control group) were recruited. Water-referenced metabolite concentrations were then computed with LCModel software. Metabolite quantification was reported in arbitrary units. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV-TR diagnosed MDD |
Sample size | 83 |
Tissue | Central; Brain; Subgenual anterior cingulate cortex; Central; Brain; Hippocampus; Central; Brain; Dorsal anterior cingulate cortex; |
Platform | MRS; MRS: Siemens 3 T Allegra system; |
PMID | |
DOI | |
Citation | Njau S, Joshi SH, Espinoza R, et al. Neurochemical correlates of rapid treatment response to electroconvulsive therapy in patients with major depression. J Psychiatry Neurosci 2017;42(1):6-16. |
Metabolite |
