Study M342
Study name | Li M 2017 |
Title | Temporal dynamics of antidepressant ketamine effects on glutamine cycling follow regional fingerprints of AMPA and NMDA receptor densities |
Overall design | To elucidate ketamine's mechanism of action, this study tested whether the clinical time course of the improvement is mirrored by the change of glutamine/glutamate ratio and if such effects show a regional and temporal specificity in two distinct subdivisions of anterior cingulate cortex (ACC) with differentalpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)/N-methyl-D-aspartate receptor profiles. In a double-blind, placebo-controlled intravenous infusion study of ketamine, glutamate and glutamine were measured in the pregenual ACC (pgACC) and the anterior midcingulate cortex at 1 and 24H post infusion with magnetic resonance spectroscopy at 7T. A total of 12 subjects in the ketamine group (ketamine group, ketamine 0.5 mg/kg continuously infusion over 40 min) and 14 subjects in the placebo group were included in the primary analysis. The glutamine/glutamate ratio change in the pgACC caused by ketamine at 24 h post infusion was reproduced in an enlarged sample (placebo group, n = 24; ketamine group, n = 20). Metabolite quantification was reported relative to brain water concentration. |
Study Type | Type3; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Not reported |
Sample size | 26 |
Tissue | Central; Brain; Anterior midcingulate cortex; Central; Brain; Pregenual anterior cingulate cortex; |
Platform | MRS; MRS: 7 T MR scanner (Siemens Healthcare, Erlangen, Germany); |
PMID | |
DOI | |
Citation | Li M, Demenescu LR, Colic L, et al. Temporal dynamics of antidepressant ketamine effects on glutamine cycling follow regional fingerprints of AMPA and NMDA receptor densities. Neuropsychopharmacology 2017;42(6):1201-9. |
Metabolite |
