Study M339
Study name | Ernst J 2017 |
Title | Increased pregenual anterior cingulate glucose and lactate concentrations in major depressive disorder |
Overall design | The aim of this study was to investigate the levels of lactate and glucose in a specific brain region, namely the pregenual anterior cingulate cortex (PACC), in patients with major depressive disorder (MDD). Proton magnetic resonance spectroscopy was used to test the hypothesis that patients with MDD have increased PACC glucose and lactate levels. In healthy (control group, n = 20) and depressed participants (depression group, n = 19), spectra were acquired from the PACC using a maximum echo J-resolved spectroscopy protocol. Both mean absolute levels and mean ratios of metabolite to total creatine levels were compared. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | Acute MDD episode |
Sample size | 39 |
Tissue | Central; Brain; Pregenual anterior cingulate cortex; |
Platform | MRS; MRS: 3 T MRI scanner (Achieva' Philips Healthcare, Best, The Netherlands); |
PMID | |
DOI | |
Citation | Ernst J, Hock A, Henning A, et al. Increased pregenual anterior cingulate glucose and lactate concentrations in major depressive disorder. Mol Psychiatry 2017;22(1):113-9. |
Metabolite | L-Lactic acid; |
