Study M337
Study name | Brennan BP 2017 |
Title | Acute change in anterior cingulate cortex GABA, but not glutamine/glutamate, mediates antidepressant response to citalopram |
Overall design | Using proton magnetic resonance spectroscopy (1H-MRS) this study examined longitudinally the effects of citalopram on glutamine/glutamate ratios and GABA levels in the pregenual anterior cingulate cortex (pgACC) of individuals with major depressive disorder (MDD). 1H-MRS scans were acquired at baseline and at days 3, 7, and 42 of citalopram treatment in unmedicated individuals with MDD (depression group, n = 19). Age- and sex-matched non-depressed comparison individuals (control group, n = 10) were scanned once. The association between 1) baseline metabolites and 2) change in metabolites from baseline to each time point and clinical response (change in Montgomery-Asberg Depression Rating Scale (MADRS) score from baseline to day 42) was assessed by longitudinal regression analysis using generalized estimating equations. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-21 >= 18 |
Sample size | 29 |
Tissue | Central; Brain; Pregenual anterior cingulate cortex; |
Platform | MRS; MRS: 3 T Siemens Trio platform (Siemens Medical Solutions USA Inc., Malvern, PA); |
PMID | |
DOI | |
Citation | Brennan BP, Admon R, Perriello C, et al. Acute change in anterior cingulate cortex GABA, but not glutamine/glutamate, mediates antidepressant response to citalopram. Psychiatry Res 2017;269:9-16. |
Metabolite |
