Study M336
Study name | Baeken C 2017 |
Title | The impact of accelerated high frequency rTMS on brain neurochemicals in treatment-resistant depression: insights from 1H MR spectroscopy |
Overall design | Right-handed antidepressant-free unipolar treatment resistant depressed (TRD) patients (depression group, n = 18) participated in this sham-controlled accelerated high frequency (aHF)-rTMS 1H MR spectroscopy study applied to the left dorsolateral prefrontal cortex (DLPFC). Baseline measurements were compared to age- and gender-matched healthy controls (control group, n = 18). Patients received 20 real or sham HF-rTMS sessions (5 sessions/day for 4 days) in the first week and the other condition in the second treatment week. 1H MR spectroscopy scans were performed at baseline (T0), after the first week (T1) and at the end of the treatment protocol after the second week (T2). We explicitly focused on neurochemical concentrations in the bilateral DLPFC and rostral anterior cingulate cortex (rACC). Metabolite quantification was reported relative to brain water concentration. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Treatment-resistant depression; Treatment-resistant depression; |
Criteria for depression | ICD-10 diagnosed MDD |
Sample size | 36 |
Tissue | Central; Brain; Dorsolateral prefrontal cortex; Central; Brain; Rostral anterior cingulate cortex; |
Platform | MRS; MRS: 3 T Philips MRI scanner (Achieva, software level 2.5, Philips, Best, NL); |
PMID | |
DOI | |
Citation | Baeken C, Lefaucheur JP, Van Schuerbeek P. The impact of accelerated high frequency rTMS on brain neurochemicals in treatment-resistant depression: insights from 1H MR spectroscopy. Clin Neurophysiol 2017;128(9):1664-72. |
Metabolite |
