Study M335
Study name | Abdallah CG 2017 |
Title | Metabotropic glutamate receptor 5 and glutamate involvement in major depressive disorder: a multimodal imaging study |
Overall design | The goal of the present study was to determine the role of metabotropic glutamate receptor 5 (mGluR5) in a large group of individuals with major depressive disorder (MDD) compared to healthy controls (HC) in vivo with [18F]FPEB and positron emission tomography (PET). Furthermore, we sought to determine the role glutamate plays on mGluR5 availability in MDD. Sixty-five participants (30 MDD and 35 HC) completed [18F]FPEB PET to estimate the primary outcome measure - mGluR5 volume of distribution (VT), and the secondary outcome measure - mGluR5 distribution volume ratio (DVR). A subgroup of 39 participants, including 16 MDD (depression group) and 23 HC (control group), completed proton magnetic resonance spectroscopy (1H MRS) to estimate anterior cingulate (ACC) glutamate, glutamine, and Glx (glutamate + glutamine) levels relative to creatine (Cr). Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 39 |
Tissue | Central; Brain; Anterior cingulate cortex; |
Platform | MRS; MRS: 4 T magnet (Bruker Instruments, Billerica, MA); |
PMID | |
DOI | |
Citation | Abdallah CG, Hannestad J, Mason GF, et al. Metabotropic glutamate receptor 5 and glutamate involvement in major depressive disorder: a multimodal imaging study. Biol Psychiatry Cogn Neurosci Neuroimaging 2017;2(5):449-56. |
Metabolite | (Glutamate and Glutamine)/(Creatine and Phosphocreatine) ratio; Glutamine/(Creatine and Phosphocreatine) ratio; Glutamate/(Creatine and Phosphocreatine) ratio; (Glutamate and Glutamine)/N-Acetyl aspartate ratio; (Glutamate and Glutamine)/Choline-containing compounds ratio; |
