Study M334
Study name | Jollant F 2017 |
Title | Spectroscopy markers of suicidal risk and mental pain in depressed patients |
Overall design | This study hypothesized that suicide attempters in comparison to patient controls and healthy controls would show higher intensity of cellular impairments (notably low N-acetylaspartate and high myo-inositol and choline levels), and that the above-mentioned clinical measures associated with suicidal risk would also correlate with these biochemical measures. Proton magnetic resonance spectroscopy was used to measure at-rest levels of 9 metabolites (glutamate, glutamine, glutathione, GABA, N-acetylaspartate (NAA), N-acetylaspartylglutamate, myo-inositol, aspartate, total choline), in the right dorsal prefrontal cortex of unmedicated depressed patients (depression group, n = 25) and healthy controls (control group, n = 33). Metabolite levels were compared between groups, and run correlations with 9 clinical variables relevant for suicide risk. For depressed patients, 15 of them had a personal history of suicidal act (depression with suicide attempt group) and 10 had none (depression without suicide attempt group). Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression with suicide; Depression with suicide; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-24 > 20 |
Sample size | 58 |
Tissue | Central; Brain; Dorsal prefrontal cortex; |
Platform | MRS; MRS: Siemens Magnetom Trio (Tim System 3T, MR B17) MRI scanner; |
PMID | |
DOI | |
Citation | Jollant F, Near J, Turecki G, et al. Spectroscopy markers of suicidal risk and mental pain in depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 2017; 73:64-71. |
Metabolite | N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio; Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
