Study M332

Study name

Mao N 2016

Title

Correlation between neurochemical metabolism and memory function in adolescent patients with depression: a multi-voxel 1H magnetic resonance spectroscopy study

Overall design

The aim of this study was to determine the correlation of biochemical changes in frontal white matter and gray matter with memory function in adolescent depression through magnetic resonance spectroscopy (MRS). Multi-voxel proton magnetic resonance spectroscopy (1H-MRS) was utilized to detect biochemical abnormalities in dorsolateral prefrontal white matter and anterior cingulate gray matter and to determine the correlation of biochemical changes with memory function in depressed adolescents. Depressed patients (depression group, n = 24) and healthy controls (control group, n = 23) were enrolled in this study. MRS was performed to assess the N-acetylaspartate (NAA)/creatine Cr and choline (Cho)/Cr ratios in dorsolateral prefrontal white matter and anterior cingulate gray matter of participants. Memory function was measured on the basis of Wechsler Memory Scale scores, and depression was diagnosed on the basis of clinical observation, interview, and Hamilton Depression Rating Scale scores. Metabolite quantification was reported relative to total creatine as the reference peak.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Pediatric depression; Pediatric depression;

Criteria for depression

DSM-IV diagnosed MDD, HAMD-17 >= 18

Sample size

47

Tissue

Central; Brain; Dorsolateral prefrontal white matter;

Central; Brain; Anterior cingulate gray matter;

Platform

MRS; MRS: 3.0 T Siemens Skyra MR system (Allegra, VA25, Siemens, Erlangen, Germany);

PMID

26556039

DOI

10.1111/pcn.12372

Citation

Mao N, Fang J, Xie H, et al. Correlation between neurochemical metabolism and memory function in adolescent patients with depression: a multi-voxel 1H magnetic resonance spectroscopy study. Psychiatry Clin Neurosci 2016;70(4):167-74.

Metabolite

N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio;

Choline-containing compounds/(Creatine and Phosphocreatine) ratio;