Study M331
Study name | Zhang L 2016 |
Title | Morphological and metabolic alteration of cerebellum in patients with post-stroke depression |
Overall design | The aim of this study was to study morphological and metabolic changes of cerebellum with multimodality magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H-MRS), respective, to explore correlation between cerebellum alteration and severity of depression in patients with post-stroke depression. Sixty subjects, including 40 stroke patients and healthy volunteers (control group, n = 20) were enrolled. Depression of stroke patients was tested by Self-rating Depression Scale and Hamilton Depression Scale, based on which stroke-patients were grouped into post-stroke depression (stroke with depression group, n = 20) and without post-stroke depression (stroke without depression group, n = 20). Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Post-stroke depression; Post-stroke depression; |
Criteria for depression | CCMD-3 diagnosed MDD, Self-rating Depression Scale >= 30, HAMD-17 > 7 |
Sample size | 60 |
Tissue | Central; Brain; Cerebellum; |
Platform | MRS; MRS: Siemens 3.0 T Trio MRI scanner; |
PMID | |
DOI | |
Citation | Zhang L, Sui R, Zhang L, et al. Morphological and metabolic alteration of cerebellum in patients with post-stroke depression. Cell Physiol Biochem 2016;40(3-4):420-30. |
Metabolite | Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
