Study M329
Study name | Yang XR 2016 |
Title | Proton spectroscopy study of the dorsolateral prefrontal cortex in youth with familial depression |
Overall design | Proton magnetic resonance spectroscopy (1 H-MRS) was used to examine the metabolite choline (glycerophosphocholine plus phosphocholine), which is used as an index of membrane integrity in the left dorsolateral prefrontal cortex (DLPFC), in adolescents and young adults with major depressive disorder (MDD) who were treatment-resistant and had a positive family history compared to healthy controls. Differences in the choline resonance indicate an imbalance between synthesis and degradation activity of neuronal and glia membrane phospholipids. Adolescents with MDD (depression group, n = 17) and healthy controls (control group, n = 11) underwent 1H-MRS. A short echo point-resolved spectroscopy (echo time = 30 ms, repetition time = 2000 ms) protocol was used with a voxel (4.5 cm3 , 128 averages) placed within the left DLPFC. Metabolite quantification was reported in absolute concentrations. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Treatment-resistant depression; Treatment-resistant depression; |
Criteria for depression | DSM-IV-TR diagnosed MDD, CDRS-R >= 40 |
Sample size | 28 |
Tissue | Central; Brain; Dorsolateral prefrontal cortex; |
Platform | MRS; MRS: 3 T GEp MR750w scanner; |
PMID | |
DOI | |
Citation | Yang XR, Langevin LM, Jaworska N, et al. Proton spectroscopy study of the dorsolateral prefrontal cortex in youth with familial depression. Psychiatry Clin Neurosci 2016;70(7):269-77. |
Metabolite |
