Study M327

Study name

Tan HZ 2016

Title

Main effects of diagnoses, brain regions, and their interaction effects for cerebral metabolites in bipolar and unipolar depressive disorders

Overall design

This study hypothesized that abnormalities of metabolites in multiple sub-regions of gray matter in brain region might be happened in patients with bipolar depressive disorder (BDd) and unipolar depressive disorder (UDd). BDd patients (bipolar depression group, n = 13), UDd patients (depression group, n = 20) and 20 healthy controls (control group, n = 20) were enrolled to investigate these abnormalities. Absolute concentrations of 5 cerebral metabolites (glutamate-glutamine (Glx), N-acetylaspartate (NAA), choline (Cho), myo-inositol (mI), creatine (Cr), parietal cortex (PC)) were measured from 4 subregions (the medial frontal cortex (mPFC), anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), and parietal cortex (PC)) of gray matter. Main and interaction effects of cerebral metabolites across subregions of gray matter were evaluated. Metabolite quantification was reported in absolute concentrations.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD, HAMD-17 >= 17

Sample size

40

Tissue

Central; Brain; Anterior cingulate cortex;

Central; Brain; Medial prefrontal cortex;

Central; Brain; Parietal cortex;

Central; Brain; Posterior cingulate cortex;

Platform

MRS; MRS: 3.0 T GE Signa MR scanner (General Electric, Milwaukee, WI, USA);

PMID

27869127

DOI

10.1038/srep37343

Citation

Tan HZ, Li H, Liu CF, et al. Main effects of diagnoses, brain regions, and their interaction effects for cerebral metabolites in bipolar and unipolar depressive disorders. Sci Rep 2016;6:37343.

Metabolite

myo-Inositol;

N-Acetyl-L-aspartic acid;

Glutamate and Glutamine;

Creatine and Phosphocreatine;