Study M326
Study name | Li Y 2016 |
Title | Evaluating metabolites in patients with major depressive disorder who received mindfulness-based cognitive therapy and healthy controls using short echo MRSI at 7 Tesla |
Overall design | The aim of this study was to evaluate differences in metabolite levels between unmedicated patients with major depressive disorder (MDD) and healthy controls, to assess changes in metabolites in patients after they completed an 8-week course of mindfulness-based cognitive therapy (MBCT), and to exam the correlation between metabolites and depression severity. Patients with MDD (depression group, n = 16) and age- and gender-matched healthy controls (control group, n = 10) were studied using 3D short echo-time (20 ms) magnetic resonance spectroscopic imaging (MRSI) at 7 Tesla. Relative metabolite ratios were estimated in five regions of interest corresponding to insula, anterior cingulate cortex (ACC), caudate, putamen, and thalamus. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 26 |
Tissue | Central; Brain; Anterior cingulate cortex; Central; Brain; Insula; Central; Brain; Caudate; Central; Brain; Putamen; Central; Brain; Thalamus; |
Platform | MRS; MRS: GE 7 T MR950 scanner (GE Healthcare, Waukesha, WI, USA); |
PMID | |
DOI | |
Citation | Li Y, Jakary A, Gillung E, et al. Evaluating metabolites in patients with major depressive disorder who received mindfulness-based cognitive therapy and healthy controls using short echo MRSI at 7 Tesla. MAGMA 2016;29(3):523-33. |
Metabolite | N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio; Choline-containing compounds/(Creatine and Phosphocreatine) ratio; myo-Inositol/(Creatine and Phosphocreatine) ratio; |
