Study M325

Study name

Li H 2016

Title

Differential neurometabolite alterations in brains of medication-free individuals with bipolar disorder and those with unipolar depression: a two-dimensional proton magnetic resonance spectroscopy study

Overall design

In this study, direct comparisons were conducted between medication-free individuals with bipolar disorder (BD) and those with unipolar depression (UD) in terms of the neurometabolites in the anterior cingulate cortex (ACC), medial prefrontal cortex (mPFC), parietal cortex (PC), and posterior cingulate cortex (PCC) of the brain. Participants included medication-free patients with BD (bipolar depression group, n = 14) or UD (depression group, n = 20), and matched healthy controls (control group, n = 20). All patients were in the depressive state and had similar symptoms. All subjects were subjected to a multi-voxel proton magnetic resonance spectroscopy procedure with a 3.0 T GE Signa MR scanner. After post-processing, the absolute concentrations of glycerophosphocholine + phosphocholine (GPC + PC), phosphocreatine + creatine (PCr + Cr), Glx (glutamate + glutamine), myo-inositol (MI), and N-acetyl aspartate (NAA) from the above brain regions were compared across the three groups. Metabolite quantification was reported in absolute concentrations.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD

Sample size

40

Tissue

Central; Brain; Anterior cingulate cortex;

Central; Brain; Posterior cingulate cortex;

Central; Brain; Medial prefrontal cortex;

Central; Brain; Parietal cortex;

Platform

MRS; MRS: 3.0 T GE Signa MR scanner (General Electric, Milwaukee, WI, USA);

PMID

27870506

DOI

10.1111/bdi.12445

Citation

Li H, Xu H, Zhang Y, et al. Differential neurometabolite alterations in brains of medication-free individuals with bipolar disorder and those with unipolar depression: a two-dimensional proton magnetic resonance spectroscopy study. Bipolar Disord 2016;18(7):583-590.

Metabolite

N-Acetyl-L-aspartic acid;

Glutamate and Glutamine;

Choline-containing compounds;

Creatine and Phosphocreatine;