Study M323

Study name

Bradley KA 2016

Title

Increased ventricular cerebrospinal fluid lactate in depressed adolescents

Overall design

The purpose of this study was to investigate mitochondrial dysfunction in medication-free adolescents with major depressive disorder (MDD) through in vivo measurements of neurometabolites using high-spatial resolution multislice/multivoxel proton magnetic resonance spectroscopy. Adolescents with MDD (depression group, n = 23) and healthy controls (control group, n = 29), ages 12-20, were scanned at 3T and concentrations of ventricular cerebrospinal fluid lactate, as well as N-acetyl-aspartate (NAA), total creatine (tCr), and total choline (tCho) in the bilateral caudate, putamen, and thalamus were reported. Metabolite quantification was reported in institutional units.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Pediatric depression; Pediatric depression;

Criteria for depression

DSM-IV-TR diagnosed MDD, CDRS-R >= 36

Sample size

44

Tissue

Central; Cerebrospinal fluid; Cerebrospinal fluid;

Central; Brain; Caudate;

Central; Brain; Putamen;

Central; Brain; Thalamus;

Platform

MRS; MRS: 3.0 T GE MRI system;

PMID

26802978

DOI

10.1016/j.eurpsy.2015.08.009

Citation

Bradley KA, Mao X, Case JA, et al. Increased ventricular cerebrospinal fluid lactate in depressed adolescents. Eur Psychiatry 2016;32:1-8.

Metabolite

L-Lactic acid;